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Consumption of a High-Fat Diet during Pregnancy Changes the Expression of Cytochrome P450 in the Livers of Infant Male Mice
https://stella.repo.nii.ac.jp/records/586
https://stella.repo.nii.ac.jp/records/586ec6fd32f-148b-4e23-b60d-814b12736f31
名前 / ファイル | ライセンス | アクション |
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BiolPharmBull_36‐4_p649.pdf (1.3 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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公開日 | 2016-02-08 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Consumption of a High-Fat Diet during Pregnancy Changes the Expression of Cytochrome P450 in the Livers of Infant Male Mice | |||||||
言語 | ||||||||
言語 | eng | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | high-fat diet | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | cytochrome P450 | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | pregnane X receptor | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | pharmacokinetics | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
資源タイプ | journal article | |||||||
著者 |
Tajima, Masataka
× Tajima, Masataka× Ikarashi, Nobutomo× Okaniwa, Takehiro× Imahori, Yukari× Saruta, Kanako× Toda, Takahiro× Ishii, Makoto× Tanaka, Yoshikazu× Machida, Yoshiaki× Ochiai, Wataru× Yamada, Harumi× Sugiyama, Kiyoshi
WEKO
554
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抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | It has been recently reported that the consumption of a high-fat diet during pregnancy exerts various effects on fetuses and newborn mice. The purpose of this study was to determine the effects of a high-fat diet during pregnancy on the expression of cytochrome P450 (CYP) in the livers of offspring. Mouse dams were fed a high-fat diet during pregnancy from the time of conception. After their birth, the newborn mice were fed a normal diet until 12 weeks of age. In the livers of the infant male mice that consumed a high-fat diet, the protein expression of CYP3A and CYP2C was decreased, and the protein expression of CYP1A and CYP2E was increased at 6 and 12 weeks of age. However, almost no changes were observed in the CYP proteins at 6 and 12 weeks of age in the livers of the infant female mice that consumed a high-fat diet. The amount of pregnane X receptor (PXR) translocated into the nucleus was reduced in the livers of infant male mice that consumed a high-fat diet. However, there was neither an increase in tumor necrosis factor-α or interleukin-1β nor a decrease in lithocholic acid. These data suggested that CYP3A and CYP2C might decrease as a result of the decrease in the amount of nuclear PXR in infant male mice that consumed a high-fat diet. The results of this study suggested that the consumption of a high-fat diet by pregnant mothers may be one explanation for individual differences in pharmacokinetics. | |||||||
書誌情報 |
Biological and Pharmaceutical Bulletin 巻 36, 号 4, p. 649-657, 発行日 2013 |
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出版者 | ||||||||
出版者 | 日本薬学会 | |||||||
ISSN | ||||||||
収録物識別子タイプ | ISSN | |||||||
収録物識別子 | 0918-6158 | |||||||
書誌レコードID | ||||||||
収録物識別子タイプ | NCID | |||||||
収録物識別子 | AA10885497 | |||||||
論文ID(NAID) | ||||||||
関連タイプ | isIdenticalTo | |||||||
識別子タイプ | NAID | |||||||
関連識別子 | 130003361405 | |||||||
DOI | ||||||||
関連タイプ | isIdenticalTo | |||||||
識別子タイプ | DOI | |||||||
関連識別子 | info:10.1248/bpb.b12-01017 | |||||||
権利 | ||||||||
権利情報 | 日本薬学会 | |||||||
フォーマット | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | application/pdf | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |