{"created":"2023-06-19T09:07:10.815290+00:00","id":586,"links":{},"metadata":{"_buckets":{"deposit":"ef450945-d84e-4764-928c-2c8439b80aea"},"_deposit":{"created_by":15,"id":"586","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"586"},"status":"published"},"_oai":{"id":"oai:stella.repo.nii.ac.jp:00000586","sets":[]},"author_link":["959","947","963","553","552","960","962","494","396","554","961","955"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"657","bibliographicPageStart":"649","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"Biological and Pharmaceutical Bulletin"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It has been recently reported that the consumption of a high-fat diet during pregnancy exerts various effects on fetuses and newborn mice. The purpose of this study was to determine the effects of a high-fat diet during pregnancy on the expression of cytochrome P450 (CYP) in the livers of offspring. Mouse dams were fed a high-fat diet during pregnancy from the time of conception. After their birth, the newborn mice were fed a normal diet until 12 weeks of age. In the livers of the infant male mice that consumed a high-fat diet, the protein expression of CYP3A and CYP2C was decreased, and the protein expression of CYP1A and CYP2E was increased at 6 and 12 weeks of age. However, almost no changes were observed in the CYP proteins at 6 and 12 weeks of age in the livers of the infant female mice that consumed a high-fat diet. The amount of pregnane X receptor (PXR) translocated into the nucleus was reduced in the livers of infant male mice that consumed a high-fat diet. However, there was neither an increase in tumor necrosis factor-α or interleukin-1β nor a decrease in lithocholic acid. These data suggested that CYP3A and CYP2C might decrease as a result of the decrease in the amount of nuclear PXR in infant male mice that consumed a high-fat diet. The results of this study suggested that the consumption of a high-fat diet by pregnant mothers may be one explanation for individual differences in pharmacokinetics.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_10001_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"130003361405","subitem_relation_type_select":"NAID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:10.1248/bpb.b12-01017","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本薬学会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10885497","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0918-6158","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tajima, 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Takahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"553","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishii, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"552","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Yoshikazu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"955","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Machida, Yoshiaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"947","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ochiai, Wataru","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"494","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000040381008","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"40381008","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40381008"}]},{"creatorNames":[{"creatorName":"Yamada, Harumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"963","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugiyama, Kiyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"554","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000080145713","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000080145713"},{"nameIdentifier":"1000080145713","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"80145713","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80145713"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-08"}],"displaytype":"detail","filename":"BiolPharmBull_36‐4_p649.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BiolPharmBull_36‐4_p649.pdf ","url":"https://stella.repo.nii.ac.jp/record/586/files/BiolPharmBull_36‐4_p649.pdf"},"version_id":"ece2bac0-946b-48c0-97c5-d8a4b64e580d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"high-fat diet","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cytochrome P450","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pregnane X receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pharmacokinetics","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Consumption of a High-Fat Diet during Pregnancy Changes the Expression of Cytochrome P450 in the Livers of Infant Male Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Consumption of a High-Fat Diet during Pregnancy Changes the Expression of Cytochrome P450 in the Livers of Infant Male Mice","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["128"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-08"},"publish_date":"2016-02-08","publish_status":"0","recid":"586","relation_version_is_last":true,"title":["Consumption of a High-Fat Diet during Pregnancy Changes the Expression of Cytochrome P450 in the Livers of Infant Male Mice"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-19T09:17:28.606987+00:00"}