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Enhanced Plasmid DNA Transfer into Tumor Cells by Nanoparticle Composed of Cholesteryl Triamine and Diamine
https://stella.repo.nii.ac.jp/records/585
https://stella.repo.nii.ac.jp/records/58500c56908-ee80-4c2b-8016-8ed560733d3f
名前 / ファイル | ライセンス | アクション |
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BiolPharmBull_36‐5_p856.pdf (3.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2016-02-08 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Enhanced Plasmid DNA Transfer into Tumor Cells by Nanoparticle Composed of Cholesteryl Triamine and Diamine | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cationic nanoparticle | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | plasmid DNA delivery | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | transfection | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cholesteryl diamine | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | cholesteryl triamine | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | tumor cell | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hattori, Yoshiyuki
× Hattori, Yoshiyuki× Nakamura, Tsukasa× Ohno, Hiroaki× Fujii, Nobutaka× Maitani, Yoshie |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Previously, we prepared cationic nanoparticles (NP and NP-N) composed of cholesteryl diamine (OH-Chol, (3S)-N-(2-(2-hydroxyethylamino)ethyl)cholesteryl-3-carboxamide) and cholesteryl triamine (OH-N-Chol, (3S)-N-(2-(2-(2-hydroxyethylamino)ethylamino)ethyl)cholesteryl-3-carboxamide), respectively, with Tween 80 for small interfering RNA (siRNA) delivery into tumor cells. In this study, we prepared NP-0.25N composed of OH-Chol and OH-N-Chol at a molar ratio of 3/1 with Tween 80, and evaluated the transfection efficiency of plasmid DNA (pDNA) into tumor cells. NP-N exhibited lower transfection activity than NP; however, NP-0.25N showed higher transfection activity than both NP and NP-N in various tumor cells. NP-0.25N increased the amount of internalized pDNA by increased cellular association, and improved the escape from endosomes after clathrin-mediated endocytosis. The results of the experiments suggested that cholesteryl triamine may have potential as a helper lipid to increase the transfection for pDNA delivery by cationic cholesterol-based nanoparticles. | |||||
書誌情報 |
Biological and Pharmaceutical Bulletin 巻 36, 号 5, p. 856-860, 発行日 2013 |
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出版者 | ||||||
出版者 | 日本薬学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0918-6158 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10885497 | |||||
論文ID(NAID) | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | NAID | |||||
関連識別子 | 130003361415 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:10.1248/bpb.b12-01062 | |||||
権利 | ||||||
権利情報 | 日本薬学会 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |