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Synthesis of Am80 (Tamibarotene) Prodrug Candidates, Congeners and Metabolites
https://stella.repo.nii.ac.jp/records/458
https://stella.repo.nii.ac.jp/records/458de98c74e-cb8b-4201-9edd-b012400b698e
名前 / ファイル | ライセンス | アクション |
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ChemPharmBull_61‐8_p846.pdf (665.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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公開日 | 2016-02-01 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Synthesis of Am80 (Tamibarotene) Prodrug Candidates, Congeners and Metabolites | |||||||
言語 | ||||||||
言語 | eng | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | Am80 | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | prodrug | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | β-oxidation | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | deuteration | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | isotope effect | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
資源タイプ | journal article | |||||||
著者 |
Muratake, Hideaki
× Muratake, Hideaki× Amano, Yohei× Toda, Takahiro× Sugiyama, Kiyoshi
WEKO
554
× Shudo, Koichi |
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抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | Compound 1 (IT-M-07000) was previously reported as a candidate prodrug of Am80 (Tamibarotene; used to treat acute promyelocytic leukemia), and shown to be efficiently metabolized to Am80 via β-oxidation. Here, we describe in detail the synthesis of 1, together with another tetradeuterated candidate prodrug, IT-YA-00616 (2), as well as two congeners, and several metabolic intermediates of 1 previously detected in mouse plasma. | |||||||
書誌情報 |
Chemical and Pharmaceutical Bulletin 巻 61, 号 8, p. 846-852, 発行日 2013 |
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出版者 | ||||||||
出版者 | 日本薬学会 | |||||||
ISSN | ||||||||
収録物識別子タイプ | ISSN | |||||||
収録物識別子 | 0009-2363 | |||||||
書誌レコードID | ||||||||
収録物識別子タイプ | NCID | |||||||
収録物識別子 | AA00602100 | |||||||
論文ID(NAID) | ||||||||
関連タイプ | isIdenticalTo | |||||||
識別子タイプ | NAID | |||||||
関連識別子 | 130003360816 | |||||||
DOI | ||||||||
関連タイプ | isIdenticalTo | |||||||
識別子タイプ | DOI | |||||||
関連識別子 | info:10.1248/cpb.c13-00356 | |||||||
権利 | ||||||||
権利情報 | 日本薬学会 | |||||||
フォーマット | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | application/pdf | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |