@article{oai:stella.repo.nii.ac.jp:00000458,
 author = {Muratake, Hideaki and Amano, Yohei and Toda, Takahiro and Sugiyama, Kiyoshi and Shudo, Koichi},
 issue = {8},
 journal = {Chemical and Pharmaceutical Bulletin},
 month = {},
 note = {application/pdf, Compound 1 (IT-M-07000) was previously reported as a candidate prodrug of Am80 (Tamibarotene; used to treat acute promyelocytic leukemia), and shown to be efficiently metabolized to Am80 via β-oxidation. Here, we describe in detail the synthesis of 1, together with another tetradeuterated candidate prodrug, IT-YA-00616 (2), as well as two congeners, and several metabolic intermediates of 1 previously detected in mouse plasma.},
 pages = {846--852},
 title = {Synthesis of Am80 (Tamibarotene) Prodrug Candidates, Congeners and Metabolites},
 volume = {61},
 year = {2013}
}