{"created":"2023-06-19T09:07:03.871667+00:00","id":458,"links":{},"metadata":{"_buckets":{"deposit":"49a8013c-09ea-4a8b-b60e-b0a8ec81f78a"},"_deposit":{"created_by":15,"id":"458","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"458"},"status":"published"},"_oai":{"id":"oai:stella.repo.nii.ac.jp:00000458","sets":[]},"author_link":["727","553","728","729","554"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"8","bibliographicPageEnd":"852","bibliographicPageStart":"846","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"Chemical and Pharmaceutical Bulletin"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Compound 1 (IT-M-07000) was previously reported as a candidate prodrug of Am80 (Tamibarotene; used to treat acute promyelocytic leukemia), and shown to be efficiently metabolized to Am80 via β-oxidation. Here, we describe in detail the synthesis of 1, together with another tetradeuterated candidate prodrug, IT-YA-00616 (2), as well as two congeners, and several metabolic intermediates of 1 previously detected in mouse plasma.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_10001_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"130003360816","subitem_relation_type_select":"NAID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:10.1248/cpb.c13-00356","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本薬学会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00602100","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0009-2363","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Muratake, Hideaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"727","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Amano, Yohei","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"728","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toda, Takahiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"553","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugiyama, Kiyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"554","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000080145713","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000080145713"},{"nameIdentifier":"1000080145713","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"80145713","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=80145713"}]},{"creatorNames":[{"creatorName":"Shudo, Koichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"729","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-01"}],"displaytype":"detail","filename":"ChemPharmBull_61‐8_p846.pdf","filesize":[{"value":"665.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ChemPharmBull_61‐8_p846.pdf ","url":"https://stella.repo.nii.ac.jp/record/458/files/ChemPharmBull_61‐8_p846.pdf"},"version_id":"f124c6f2-b0c8-48f8-9f3e-6ceb9187e7ae"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Am80","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"prodrug","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"β-oxidation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"deuteration","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"isotope effect","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Synthesis of Am80 (Tamibarotene) Prodrug Candidates, Congeners and Metabolites","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Synthesis of Am80 (Tamibarotene) Prodrug Candidates, Congeners and Metabolites","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["127"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-01"},"publish_date":"2016-02-01","publish_status":"0","recid":"458","relation_version_is_last":true,"title":["Synthesis of Am80 (Tamibarotene) Prodrug Candidates, Congeners and Metabolites"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-19T09:21:01.326684+00:00"}