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Evaluation of in Vitro and in Situ Transdermal Absorption of Drugs in Pig and Rat Skin(Pharmaceutical,Chemical)
https://stella.repo.nii.ac.jp/records/554
https://stella.repo.nii.ac.jp/records/5540b32d4b9-8c69-405f-a922-aff864affe06
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ChemPharmBull_35‐12_p4915.pdf (899.2 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2016-02-05 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Evaluation of in Vitro and in Situ Transdermal Absorption of Drugs in Pig and Rat Skin(Pharmaceutical,Chemical) | |||||||||||||||
| 言語 | en | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | penetration enhancer | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | propylene glycol | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | insulin | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | brilliant blue | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | flux | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | permeability | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | lag time | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 著者 |
Priborsky, Jan
× Priborsky, Jan
× Takayama, Kozo
× Nagai, Tsuneji
× Waitzova, Danuse
× Elis, Jiri
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| 抄録 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | The permeability characteristics of newborn pig skin and adult rat skin, either fresh or stored, to model drugs were examined and compared. Special attention was paid to the design to a new experimental system suitable for evaluation of skin permeability to various substances. Two types of model substances were used; insulin, a poorly absorbable substance with high molecular weight as a representative of peptide drugs, and brilliant blue, a low-molecular, relatively well absorbable substance. In vitro experiments performed with both substances in pig and rat gave comparable values of skin permeability. Maximum insulin concentration in the receiver solution was very similar in all experiments (164.5-180.5μU/ml/24h when Azone[○!R] was used and 136.5-178.0μU/ml/24h when N-methyl-2-pyrrolidone (NMP) was used as a penetration enhancer). The donor side concentration of insulin was 2.5mg/ml. The optimum concentrations of vehicle and penetration enhancer were 40.0% propylene glycol (PG) and 0.1% Azone[○!R] or 12.0% NMP, respectively. Brilliant blue experiments performed with the three skin preparations with 40.0% PG and 12.0% NMP gave similar values of the flux J_T and permeability P of 1.38-1.97μg/cm^2/h and 1.56×10^<-5>-2.22×10^<-5>cm/h, respectively. The concentration of brilliant blue in the donor compartment was 50mg/ml. There were differences between the lag time in pig and rat skin experiments: about 3h in the case of rat skin but 15min in pig skin. In comparison to in vitro experiments, in situ studies gave much lower penetration of both test substances expressed as concentration in the receiver compartment. In the case of insulin with Azone[○!R] or NMP in the formulation, 30 times or 17 times lower concentration was found, and in brilliant blue experiments almost 5 times lower levels were. observed. This new experimental system should be useful for examination of potential drug candidates as well as drug formulations for transdermal use. | |||||||||||||||
| 書誌情報 |
Chemical & pharmaceutical bulletin 巻 35, 号 12, p. 4915-4920, 発行日 1987-12-25 |
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| 出版者 | ||||||||||||||||
| 出版者 | 日本薬学会 | |||||||||||||||
| ISSN | ||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 00092363 | |||||||||||||||
| 書誌レコードID | ||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||
| 収録物識別子 | AA00602100 | |||||||||||||||
| 論文ID（NAID） | ||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||
| 識別子タイプ | NAID | |||||||||||||||
| 関連識別子 | 110006281745 | |||||||||||||||
| 権利 | ||||||||||||||||
| 権利情報 | 日本薬学会 | |||||||||||||||
| フォーマット | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | application/pdf | |||||||||||||||
| 著者版フラグ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
