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Iontophoretic Transdermal Delivery of Glycyrrhizin: Effects of pH, Drug Concentration, Co-ions, Current Intensity, and Chemical Enhancers
https://stella.repo.nii.ac.jp/records/456
https://stella.repo.nii.ac.jp/records/45633162e2d-375d-4558-991b-161989f65820
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ChemPharmBull_61‐12_p1275.pdf (433.9 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||
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| 公開日 | 2016-02-01 | |||||||||||||||||||
| タイトル | ||||||||||||||||||||
| タイトル | Iontophoretic Transdermal Delivery of Glycyrrhizin: Effects of pH, Drug Concentration, Co-ions, Current Intensity, and Chemical Enhancers | |||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 言語 | ||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | glycyrrhizin | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | cathodal iontophoresis | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | transdermal drug delivery | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | pig skin | |||||||||||||||||||
| キーワード | ||||||||||||||||||||
| 言語 | en | |||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||
| 主題 | chronic hepatitis | |||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||
| 著者 |
Yamamoto, Rie
× Yamamoto, Rie
× Takasuga, Shinri
× Kominami, Katsuya
× Sutoh, Chiyo
× Kinoshita, Mine
× Kanamura, Kiyoshi
× Takayama, Kozo
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| 抄録 | ||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||
| 内容記述 | The aim of the present study was to evaluate the feasibility of transdermal delivery of glycyrrhizin, an agent used in the treatment of chronic hepatitis C, by cathodal iontophoresis using Ag/AgCl electrodes in vitro. The effects of donor pH (pH 4–7), concentration of drug (0.025–0.2% (w/v)), concentration of external chloride ions (Cl−) (0–133 m<span style="font-variant: small-caps;">M</span>), current strength (0–0.5 mA/cm2), and permeation enhancers (urea and Tween 80) on the skin permeability of glycyrrhizin were examined in in vitro skin permeation studies using porcine ear skin as the membrane. The cumulative amount of permeated glycyrrhizin and the steady-state skin permeation flux of glycyrrhizin across porcine skin increased in a pH-dependent manner. The skin permeability of glycyrrhizin was independent of the concentration of drug and competed only with a high external Cl− concentration. The skin permeation flux of glycyrrhizin increased with the current (R2=0.8955). The combination of iontophoresis and enhancers provided an additive or synergistic effect, and a skin permeation flux of about 60 µg/h/cm2 was achieved. The plasma concentration of glycyrrhizin in humans, extrapolated from the in vitro steady-state permeation flux across porcine skin, was within the therapeutic level. These results suggest that cathodal iontophoresis can be used as a transdermal drug delivery system for glycyrrhizin using reasonable patch sizes and acceptable levels of current intensity. | |||||||||||||||||||
| 書誌情報 |
Chemical and Pharmaceutical Bulletin 巻 61, 号 12, p. 1275-1281, 発行日 2013 |
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| 出版者 | ||||||||||||||||||||
| 出版者 | 日本薬学会 | |||||||||||||||||||
| ISSN | ||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||
| 収録物識別子 | 0009-2363 | |||||||||||||||||||
| 書誌レコードID | ||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||
| 収録物識別子 | AA00602100 | |||||||||||||||||||
| 論文ID（NAID） | ||||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||||
| 識別子タイプ | NAID | |||||||||||||||||||
| 関連識別子 | 130003381792 | |||||||||||||||||||
| DOI | ||||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||
| 関連識別子 | info:10.1248/cpb.c13-00548 | |||||||||||||||||||
| 権利 | ||||||||||||||||||||
| 権利情報 | 日本薬学会 | |||||||||||||||||||
| フォーマット | ||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||
| 内容記述 | application/pdf | |||||||||||||||||||
| 著者版フラグ | ||||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||
