{"created":"2023-06-19T09:07:03.738936+00:00","id":456,"links":{},"metadata":{"_buckets":{"deposit":"99a5b156-8276-48ab-b2ca-ec2e07239480"},"_deposit":{"created_by":15,"id":"456","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"456"},"status":"published"},"_oai":{"id":"oai:stella.repo.nii.ac.jp:00000456","sets":[]},"author_link":["723","722","720","114","719","724","721"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1281","bibliographicPageStart":"1275","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"Chemical and Pharmaceutical Bulletin"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The aim of the present study was to evaluate the feasibility of transdermal delivery of glycyrrhizin, an agent used in the treatment of chronic hepatitis C, by cathodal iontophoresis using Ag/AgCl electrodes in vitro. The effects of donor pH (pH 4–7), concentration of drug (0.025–0.2% (w/v)), concentration of external chloride ions (Cl−) (0–133 m<span style=\"font-variant: small-caps;\">M</span>), current strength (0–0.5 mA/cm2), and permeation enhancers (urea and Tween 80) on the skin permeability of glycyrrhizin were examined in in vitro skin permeation studies using porcine ear skin as the membrane. The cumulative amount of permeated glycyrrhizin and the steady-state skin permeation flux of glycyrrhizin across porcine skin increased in a pH-dependent manner. The skin permeability of glycyrrhizin was independent of the concentration of drug and competed only with a high external Cl− concentration. The skin permeation flux of glycyrrhizin increased with the current (R2=0.8955). The combination of iontophoresis and enhancers provided an additive or synergistic effect, and a skin permeation flux of about 60 µg/h/cm2 was achieved. The plasma concentration of glycyrrhizin in humans, extrapolated from the in vitro steady-state permeation flux across porcine skin, was within the therapeutic level. These results suggest that cathodal iontophoresis can be used as a transdermal drug delivery system for glycyrrhizin using reasonable patch sizes and acceptable levels of current intensity.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_10001_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"130003381792","subitem_relation_type_select":"NAID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:10.1248/cpb.c13-00548","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本薬学会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00602100","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0009-2363","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamamoto, Rie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"719","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takasuga, Shinri","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"720","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kominami, Katsuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"721","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sutoh, Chiyo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"722","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kinoshita, Mine","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"723","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanamura, Kiyoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"724","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takayama, Kozo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"114","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000000130758","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000000130758"},{"nameIdentifier":"1000000130758","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"130758","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=130758"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-01"}],"displaytype":"detail","filename":"ChemPharmBull_61‐12_p1275.pdf","filesize":[{"value":"433.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ChemPharmBull_61‐12_p1275.pdf ","url":"https://stella.repo.nii.ac.jp/record/456/files/ChemPharmBull_61‐12_p1275.pdf"},"version_id":"ed2faaf6-0b6d-4a61-ba53-1b14c084129c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"glycyrrhizin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cathodal iontophoresis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"transdermal drug delivery","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pig skin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chronic hepatitis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Iontophoretic Transdermal Delivery of Glycyrrhizin: Effects of pH, Drug Concentration, Co-ions, Current Intensity, and Chemical Enhancers","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Iontophoretic Transdermal Delivery of Glycyrrhizin: Effects of pH, Drug Concentration, Co-ions, Current Intensity, and Chemical Enhancers","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["127"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-01"},"publish_date":"2016-02-01","publish_status":"0","recid":"456","relation_version_is_last":true,"title":["Iontophoretic Transdermal Delivery of Glycyrrhizin: Effects of pH, Drug Concentration, Co-ions, Current Intensity, and Chemical Enhancers"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-19T09:21:04.896623+00:00"}