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6-Acyldecahydro[1,6]naphthyridineのマウスにおける抗侵害作用
https://stella.repo.nii.ac.jp/records/416
https://stella.repo.nii.ac.jp/records/4169601c112-ad67-4c63-8d15-2e64bd92ff34
名前 / ファイル | ライセンス | アクション |
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YakuShi_123-5_p337.pdf (546.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||
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公開日 | 2016-01-29 | |||||||||||
タイトル | ||||||||||||
タイトル | 6-Acyldecahydro[1,6]naphthyridineのマウスにおける抗侵害作用 | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | Structure Activity Relation Study of Matrine-Type Alkaloids Part III | |||||||||||
言語 | ||||||||||||
言語 | jpn | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | structure activity relatioship | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | antinociception | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | matrine | |||||||||||
資源タイプ | ||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
資源タイプ | journal article | |||||||||||
著者 |
小橋, 精一
× 小橋, 精一× 久保, 元× 山内, 貴靖× 東山, 公男
WEKO
99
× Kobashi, Seiichi× Kubo, Hajime× Yamauchi, Takayasu× Higashiyama, Kimio
WEKO
619
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抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | 6-Acyldecahydro[l,6]naphthyridines were synthesized as derivatives of matrine-type and allomatrine-type alkaloids, and the structure-activity relations were examined by the acetic acid-induced abdominal contraction test. All synthesized derivatives produced the antinociception in mice. The antinociceptive potencies of 15a-c and 16a-c were lower than those of 17a-c, 18a-c, 19a-c and 20a-c. Furthermore, those of the matrine-type derivatives 17b and 17c are greater than other derivatives. These findings suggest that less hindered tertiary amine and highly lipophilic acyl group are better functional groups for the greater antinociceptive potencies. Furthermore, these findings suggest that A or B ring of 1 and 2 are not essential for the antinociceptive effect. | |||||||||||
書誌情報 |
藥學雜誌 en : Journal of the Pharmaceutical Society of Japan 巻 123, 号 5, p. 337-347, 発行日 2003-05-01 |
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出版者 | ||||||||||||
出版者 | 日本薬学会 | |||||||||||
ISSN | ||||||||||||
収録物識別子タイプ | ISSN | |||||||||||
収録物識別子 | 00316903 | |||||||||||
書誌レコードID | ||||||||||||
収録物識別子タイプ | NCID | |||||||||||
収録物識別子 | AN00284903 | |||||||||||
論文ID(NAID) | ||||||||||||
関連タイプ | isIdenticalTo | |||||||||||
識別子タイプ | NAID | |||||||||||
関連識別子 | 110003666117 | |||||||||||
DOI | ||||||||||||
関連タイプ | isIdenticalTo | |||||||||||
識別子タイプ | DOI | |||||||||||
関連識別子 | info:doi/10.1248/yakushi.123.337 | |||||||||||
権利 | ||||||||||||
権利情報 | 日本薬学会 | |||||||||||
フォーマット | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | application/pdf | |||||||||||
著者版フラグ | ||||||||||||
出版タイプ | VoR | |||||||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |