{"created":"2023-06-19T09:07:01.411334+00:00","id":416,"links":{},"metadata":{"_buckets":{"deposit":"dd609ee1-0023-47f9-81fb-5c775762d8e4"},"_deposit":{"created_by":15,"id":"416","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"416"},"status":"published"},"_oai":{"id":"oai:stella.repo.nii.ac.jp:00000416","sets":[]},"author_link":["618","617","619","459","176","124","616","99"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"347","bibliographicPageStart":"337","bibliographicVolumeNumber":"123","bibliographic_titles":[{"bibliographic_title":"藥學雜誌"},{"bibliographic_title":"Journal of the Pharmaceutical Society of Japan","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"6-Acyldecahydro[l,6]naphthyridines were synthesized as derivatives of matrine-type and allomatrine-type alkaloids, and the structure-activity relations were examined by the acetic acid-induced abdominal contraction test. All synthesized derivatives produced the antinociception in mice. The antinociceptive potencies of 15a-c and 16a-c were lower than those of 17a-c, 18a-c, 19a-c and 20a-c. Furthermore, those of the matrine-type derivatives 17b and 17c are greater than other derivatives. These findings suggest that less hindered tertiary amine and highly lipophilic acyl group are better functional groups for the greater antinociceptive potencies. Furthermore, these findings suggest that A or B ring of 1 and 2 are not essential for the antinociceptive effect.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_10001_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110003666117","subitem_relation_type_select":"NAID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1248/yakushi.123.337","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本薬学会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00284903","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00316903","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小橋, 精一"},{"creatorName":"コバシ, セイイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"459","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"久保, 元"},{"creatorName":"クボ, ハジメ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"124","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山内, 貴靖"},{"creatorName":"ヤマウチ, タカヤス","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"176","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"東山, 公男"},{"creatorName":"ヒガシヤマ, キミオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"99","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000070101582","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000070101582"},{"nameIdentifier":"1000070101582","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"70101582","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70101582"}]},{"creatorNames":[{"creatorName":"Kobashi, Seiichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"616","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kubo, Hajime","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"617","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamauchi, Takayasu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"618","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higashiyama, Kimio","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"619","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000070101582","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000070101582"},{"nameIdentifier":"1000070101582","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"70101582","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70101582"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-01-29"}],"displaytype":"detail","filename":"YakuShi_123-5_p337.pdf","filesize":[{"value":"546.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"YakuShi_123-5_p337.pdf ","url":"https://stella.repo.nii.ac.jp/record/416/files/YakuShi_123-5_p337.pdf"},"version_id":"d96abd46-c867-48bc-815e-fd3c54637cb9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"structure activity relatioship","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"antinociception","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"matrine","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"6-Acyldecahydro[1,6]naphthyridineのマウスにおける抗侵害作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"6-Acyldecahydro[1,6]naphthyridineのマウスにおける抗侵害作用"},{"subitem_title":"Structure Activity Relation Study of Matrine-Type Alkaloids Part III","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["125"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-01-29"},"publish_date":"2016-01-29","publish_status":"0","recid":"416","relation_version_is_last":true,"title":["6-Acyldecahydro[1,6]naphthyridineのマウスにおける抗侵害作用"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-19T09:22:12.901176+00:00"}