{"created":"2023-06-19T09:07:10.441745+00:00","id":579,"links":{},"metadata":{"_buckets":{"deposit":"9313f415-36e1-4014-896f-a6caf03f2e23"},"_deposit":{"created_by":15,"id":"579","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"579"},"status":"published"},"_oai":{"id":"oai:stella.repo.nii.ac.jp:00000579","sets":[]},"author_link":["513","941","940","514","575","512"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"1061","bibliographicPageStart":"1056","bibliographicVolumeNumber":"37","bibliographic_titles":[{"bibliographic_title":"Biological and Pharmaceutical Bulletin"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Diabetes is characterized by the development of endothelial dysfunction, which affects both nitric oxide (NO)-mediated relaxation and endothelium-derived contracting factors, associated with vascular oxidative stress. There is a growing body of evidence suggesting that polyphenols have several beneficial effects, such as antioxidant and anti-inflammatory activities. This study investigated whether short-term treatment with polyphenols (chlorogenic acid (CA), morin (MO), resveratrol (RV)) can improve endothelial dysfunction related to diabetes. Aorta reactivity was determined in organ chambers, and we measured NO production and thromboxane B2 (TXB2; a metabolite of TXA2) from aortas in response to acetylcholine (ACh). Streptozotocin (STZ)-induced diabetic mice (16 weeks) were injected with solvent (ethanol, 10% v/v; intraperitoneally (i.p.)), CA (0.03 mmol/kg/d), MO (0.03 mmol/kg/d), and RV (0.03 mmol/kg/d) for 5 d. The ACh-induced endothelium-dependent relaxation was markedly reduced in rings of STZ-induced diabetic mice compared to controls. The treatment with polyphenols (significantly: MO, tendency: CA and RV) for only 5 d improved the NO components of relaxation, but did not normalize ACh-stimulated NO production. However, polyphenol treatment suppressed the ACh-stimulated level of TXB2 in aortas from STZ-induced diabetic mice. Thus, treatment with polyphenols caused basal NO production and a prompt improvement of the endothelial function in diabetic mice, and this may involve the normalization of TXA2 levels, not NO production, under ACh stimulation.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_10001_relation_12":{"attribute_name":"論文ID(NAID)","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"130004147353","subitem_relation_type_select":"NAID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:10.1248/bpb.b14-00157","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本薬学会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10885497","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0918-6158","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Taguchi, Kumiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"513","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hida, Mari","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"940","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Takayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"512","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000030366835","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"30366835","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30366835"}]},{"creatorNames":[{"creatorName":"Ikeuchi-Takahashi, Yuri","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"941","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000010339525","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"10339525","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10339525"}]},{"creatorNames":[{"creatorName":"Onishi, Hiraku","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"575","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000000160565","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"160565","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=160565"}]},{"creatorNames":[{"creatorName":"Kobayashi, Tsuneo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"514","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000090339523","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"90339523","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90339523"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-08"}],"displaytype":"detail","filename":"BiolPharmBull_37‐6_p1056.pdf","filesize":[{"value":"603.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"BiolPharmBull_37‐6_p1056.pdf ","url":"https://stella.repo.nii.ac.jp/record/579/files/BiolPharmBull_37‐6_p1056.pdf"},"version_id":"9ca93ac5-5153-4f8c-a9ab-2bd34919b4ff"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"polyphenol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelial dysfunction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nitric oxide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"thromboxane A2","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of Short-term Polyphenol Treatment on Endothelial Dysfunction and Thromboxane A2 Levels in Streptozotocin-Induced Diabetic Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of Short-term Polyphenol Treatment on Endothelial Dysfunction and Thromboxane A2 Levels in Streptozotocin-Induced Diabetic Mice","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["128"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-08"},"publish_date":"2016-02-08","publish_status":"0","recid":"579","relation_version_is_last":true,"title":["Effect of Short-term Polyphenol Treatment on Endothelial Dysfunction and Thromboxane A2 Levels in Streptozotocin-Induced Diabetic Mice"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-19T09:17:38.096626+00:00"}