{"created":"2023-06-19T09:07:04.687050+00:00","id":472,"links":{},"metadata":{"_buckets":{"deposit":"71b8a882-0878-40da-a302-e9494d6cae5a"},"_deposit":{"created_by":15,"id":"472","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"472"},"status":"published"},"_oai":{"id":"oai:stella.repo.nii.ac.jp:00000472","sets":[]},"author_link":["506","380","114","555","707"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"93","bibliographicPageStart":"86","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"Chemical and Pharmaceutical Bulletin"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The precipitation of phenytoin sodium injection provoked by mixing with infusion fluids renders its use in clinical practice difficult, as rapid intravenous (i.v.) push and i.v. infusion are supposed to be avoided. As some of its aspects remain unclear, this study tried to elucidate this precipitation mechanism. In particular, this study focused on the significant precipitation induced by glucose infusion fluid. The precipitation provoked by 5% glucose infusion fluid was obviously different from the precipitation that accompanied simple pH reduction, in terms of the growth mode and morphology of crystals. In addition, the effect of glucose was partially unrelated to pH reduction. NMR measurements including a two-dimensional nuclear Overhauser effect spectroscopy (2D-NOESY) spectrum indicated the specific interaction between glucose and propylene glycol, which is incorporated into phenytoin sodium injection as a solubilizing agent. These results led to the conclusion that this interaction was crucial for the precipitation of phenytoin, as it diminished the solubilizing effect of propylene glycol, resulting in the enhancement of the crystallization of phenytoin. The determination of phenytoin solubility in aqueous solutions at different pH values revealed that phenytoin incorporated in the admixture could be dissolved completely, as long as the injection was diluted with saline or water. These findings offer a profound insight into the formulation design of phenytoin sodium injection and its use in clinical practice.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_10001_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"130001852352","subitem_relation_type_select":"NAID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:10.1248/cpb.60.86","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本薬学会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00602100","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0009-2363","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Onuki, Yoshinori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"380","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000010350224","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"10350224","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10350224"}]},{"creatorNames":[{"creatorName":"Ikegami-Kawai, Mayumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishitsuka, Kazumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"555","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hayashi, Yoshihiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"506","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takayama, Kozo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"114","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000000130758","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000000130758"},{"nameIdentifier":"1000000130758","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"130758","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=130758"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-03"}],"displaytype":"detail","filename":"ChemPharmBull_60‐1_p86.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ChemPharmBull_60‐1_p86.pdf ","url":"https://stella.repo.nii.ac.jp/record/472/files/ChemPharmBull_60‐1_p86.pdf"},"version_id":"5b7a47a2-2555-4bdf-8f30-e873d4c5245f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"phenytoin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"precipitation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"glucose infusion fluid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"propylene glycol","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"2-dimensional nuclear Overhauser effect spectroscopy","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A 5% Glucose Infusion Fluid Provokes Significant Precipitation of Phenytoin Sodium Injection via Interruption of the Cosolvent Effect of Propylene Glycol.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A 5% Glucose Infusion Fluid Provokes Significant Precipitation of Phenytoin Sodium Injection via Interruption of the Cosolvent Effect of Propylene Glycol.","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["127"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-03"},"publish_date":"2016-02-03","publish_status":"0","recid":"472","relation_version_is_last":true,"title":["A 5% Glucose Infusion Fluid Provokes Significant Precipitation of Phenytoin Sodium Injection via Interruption of the Cosolvent Effect of Propylene Glycol."],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-19T09:20:42.134447+00:00"}