{"created":"2023-06-19T09:07:03.803421+00:00","id":457,"links":{},"metadata":{"_buckets":{"deposit":"1b07b929-2554-4807-a532-a5ceef5a5e72"},"_deposit":{"created_by":15,"id":"457","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"457"},"status":"published"},"_oai":{"id":"oai:stella.repo.nii.ac.jp:00000457","sets":[]},"author_link":["575","726"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"912","bibliographicPageStart":"902","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"Chemical and Pharmaceutical Bulletin"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A conjugate between prednisolone (PD) and chondroitin sulfate (CS) with glycine as a linker was prepared in order to obtain an effective macromolecular prodrug against inflammatory disease, especially rheumatoid arthritis. First, PD was converted to the N-trityl-glycine ester (Tr-GP), and the glycine ester of PD (GP) was obtained by detritylation of Tr-GP. Then, GP and CS were condensed with water-soluble carbodiimide to yield CS-GP. The obtained conjugate had a PD content of 2.24% (w/w). Conversion characteristics were investigated for GP and CS-GP to evaluate their potential as a prodrug. In the stability test of GP, PD was released well in the buffer at pH 6–7.4, but degraded rapidly at pH 8 without sufficient release of PD. As to CS-GP, PD was released more slowly than in GP, and the release rate rose with the increase in the medium pH. PD was released gradually from CS-GP over 24 h at a physiological pH. The conversion profiles of both GP and CS-GP almost followed pseudo-first order kinetics. The calculated conversion rate constants supported the gradual and effective release from CS-GP. The release rate of PD from GP and CS-GP was accelerated by the addition of rat plasma, but the promotion of release from CS-GP was small, suggesting that PD should be released gradually from CS-GP in the systemic circulation. It was demonstrated from the preliminary pharmacological study using rats with adjuvant-induced arthritis that CS-GP had high anti-inflammatory potential against arthritis.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_10001_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"130003360823","subitem_relation_type_select":"NAID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:10.1248/cpb.c13-00189","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本薬学会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00602100","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0009-2363","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Onishi, Hiraku","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"575","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000000160565","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"160565","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=160565"}]},{"creatorNames":[{"creatorName":"Matsuyama, Mototaka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"726","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-01"}],"displaytype":"detail","filename":"ChemPharmBull_61‐9_p902.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ChemPharmBull_61‐9_p902.pdf ","url":"https://stella.repo.nii.ac.jp/record/457/files/ChemPharmBull_61‐9_p902.pdf"},"version_id":"c1c2b0f4-22b7-4b24-a673-e539b137fe0b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"prednisolone","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"chondroitin sulfate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"conjugate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"prodrug","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"conversion rate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"adjuvant-induced arthritis","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Conjugate between Chondroitin Sulfate and Prednisolone with a Glycine Linker: Preparation and in Vitro Conversion Analysis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Conjugate between Chondroitin Sulfate and Prednisolone with a Glycine Linker: Preparation and in Vitro Conversion Analysis","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["127"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-01"},"publish_date":"2016-02-01","publish_status":"0","recid":"457","relation_version_is_last":true,"title":["Conjugate between Chondroitin Sulfate and Prednisolone with a Glycine Linker: Preparation and in Vitro Conversion Analysis"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-19T09:21:02.399100+00:00"}