{"created":"2023-06-19T09:07:03.649935+00:00","id":454,"links":{},"metadata":{"_buckets":{"deposit":"f63f7645-6ea1-4211-b627-c72eeca8a90e"},"_deposit":{"created_by":15,"id":"454","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"454"},"status":"published"},"_oai":{"id":"oai:stella.repo.nii.ac.jp:00000454","sets":[]},"author_link":["716","712","498","711","714","713","715"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"159","bibliographicPageStart":"153","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"Chemical and Pharmaceutical Bulletin"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The purpose of this study was to develop a novel simulation program to accurately predict the maximum product temperature and the primary drying time in lyophilization using the predictive model for dry layer resistance, which is the resistance of dried cake against water vapor flow. Ten percent sucrose aqueous solution was selected as a model formulation. It was demonstrated that the deviations between the predicted and measured maximum product temperature were attributed to the error of dry layer resistance at a given drying condition, which was different from the measured dry layer resistance in a preliminary lyophilization run for the simulation program. However, when the predictive model of dry layer resistance was used for the simulation program, the model remarkably enhanced the accuracy of the simulation program to predict the maximum product temperature and primary drying time under various operating conditions. Furthermore, the primary drying condition required for minimized drying at a close collapse temperature was successfully discovered through one preliminary run. Therefore, it is expected that the developed simulation program is useful for designing the lyophilization cycle without a trial and error approach.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_10001_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"130003390757","subitem_relation_type_select":"NAID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:10.1248/cpb.c13-00674","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本薬学会"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0009-2363","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kodama, Tatsuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"711","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sawada, Hiroyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"712","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hosomi, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"713","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takeuchi, Masahito","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"714","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakiyama, Naoki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"715","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yonemochi, Etsuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"498","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000040201090","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"40201090","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40201090"}]},{"creatorNames":[{"creatorName":"Terada, Katsuhide","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"716","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-01"}],"displaytype":"detail","filename":"ChemPharmBull_62‐2_p153.pdf","filesize":[{"value":"673.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ChemPharmBull_62‐2_p153.pdf ","url":"https://stella.repo.nii.ac.jp/record/454/files/ChemPharmBull_62‐2_p153.pdf"},"version_id":"931506ed-26a5-4697-9876-69e36549e419"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"simulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"dry layer mass transfer resistance","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"maximum product temperature","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"primary drying time","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Optimization of Primary Drying Condition for Pharmaceutical Lyophilization Using a Novel Simulation Program with a Predictive Model for Dry Layer Resistance","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Optimization of Primary Drying Condition for Pharmaceutical Lyophilization Using a Novel Simulation Program with a Predictive Model for Dry Layer Resistance","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["127"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-01"},"publish_date":"2016-02-01","publish_status":"0","recid":"454","relation_version_is_last":true,"title":["Optimization of Primary Drying Condition for Pharmaceutical Lyophilization Using a Novel Simulation Program with a Predictive Model for Dry Layer Resistance"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-19T09:21:09.285755+00:00"}