{"created":"2023-06-19T09:07:03.604586+00:00","id":453,"links":{},"metadata":{"_buckets":{"deposit":"75860b65-55e4-4e16-b17c-d74a22f3efc7"},"_deposit":{"created_by":15,"id":"453","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"453"},"status":"published"},"_oai":{"id":"oai:stella.repo.nii.ac.jp:00000453","sets":[]},"author_link":["635","710","708","706","380","114","97","709","707"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"993","bibliographicPageStart":"989","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"Chemical and Pharmaceutical Bulletin"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The crystallization of phenytoin occurring after its dilution with infusion fluid is a major concern in the clinical use of injectable phenytoin. To gain further understanding of the crystallization, this study assessed details of the involvement of glucose in this action. For sample preparation, phenytoin crystals were created by diluting the injectable phenytoin with infusion fluids with different glucose concentrations at different temperature, and then the characteristics of the crystallization (e.g., crystal size in the long direction, accumulated amount over 24 h, and crystallization rate constant) were measured. Results of the analysis of variance indicated that the glucose concentration and temperature had significant impacts on the crystallization. The mode of action of the glucose concentration was suggested to be different from that of the incubation temperature. This study also examined the molecular mobility of components (i.e., glucose, propylene glycol, phenytoin) in the admixtures using diffusion NMR techniques. The findings will provide valuable information for the clinical use of injectable phenytoin.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_10001_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"130004693777","subitem_relation_type_select":"NAID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:10.1248/cpb.c14-00353","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本薬学会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA00602100","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0009-2363","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Onuki, Yoshinori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"380","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000010350224","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"10350224","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=10350224"}]},{"creatorNames":[{"creatorName":"Hasegawa, Naoki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"706","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikegami-Kawai, Mayumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"707","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suematsu, Takako","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"708","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakurai, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"709","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shirozu, Shunsuke","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"710","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsubuki, Masayoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"97","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000090163865","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000090163865"},{"nameIdentifier":"1000090163865","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"90163865","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90163865"}]},{"creatorNames":[{"creatorName":"Obata, Yasuko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"635","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000020260979","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"20260979","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20260979"}]},{"creatorNames":[{"creatorName":"Takayama, Kozo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"114","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000000130758","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000000130758"},{"nameIdentifier":"1000000130758","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"130758","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=130758"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-01"}],"displaytype":"detail","filename":"ChemPharmBull_62‐10_p989.pdf","filesize":[{"value":"726.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ChemPharmBull_62‐10_p989.pdf ","url":"https://stella.repo.nii.ac.jp/record/453/files/ChemPharmBull_62‐10_p989.pdf"},"version_id":"63a5774c-b833-48a3-8067-97e7f9791ec7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"phenytoin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"crystallization characteristic","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"glucose infusion fluid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Johnson–Mehl–Avrami model","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"diffusion coefficient","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Contribution of Glucose to Crystallization of Phenytoin in Injectable Dosage Form by Dilution with Infusion Fluids","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Contribution of Glucose to Crystallization of Phenytoin in Injectable Dosage Form by Dilution with Infusion Fluids","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["127"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-01"},"publish_date":"2016-02-01","publish_status":"0","recid":"453","relation_version_is_last":true,"title":["Contribution of Glucose to Crystallization of Phenytoin in Injectable Dosage Form by Dilution with Infusion Fluids"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-19T09:21:11.325454+00:00"}