{"created":"2023-06-19T09:07:03.165042+00:00","id":445,"links":{},"metadata":{"_buckets":{"deposit":"b0eccfda-5f5f-4493-b642-b21bd1384a28"},"_deposit":{"created_by":15,"id":"445","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"445"},"status":"published"},"_oai":{"id":"oai:stella.repo.nii.ac.jp:00000445","sets":[]},"author_link":["694","595","693","130"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"532","bibliographicPageStart":"525","bibliographicVolumeNumber":"47","bibliographic_titles":[{"bibliographic_title":"Journal of health science"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Endothelin-1(ET-1) is known as a potent stimulator of cell proliferation and as a vasoconstrictor. It is believed that ET-1 contributes to the development of arterial diseases such as atherosclerosis. In this study, we demonstrated the expression of tropoelastin and lysyl oxidase(LO) on gene levels as induced by ET-1 in cultured smooth muscle cells(SMCs). ET-1 stimulated cell proliferation in a dose-dependent manner, and the level of this proliferation increased about 1.3-fold at 100 nM of ET-1. ET-1 suppressed the tropoelastin protein synthesis in a dose-dependent and time-dependent manner. In addition, ET-1 dose-dependently suppressed the tropoelastin and LO mRNA expression. The tropoelastin and LO mRNA levels decreased to about half and 4/5, respectively, at 100 nM of ET-1. The inhibition of elastin synthesis was completely prevented by BQ123, an endothelin receptor A(ET_A) antagonist. These results indicate that ET-1 can modulate the tropoelastin and LO mRNA expression via an ET_A receptor in cultured SMC and that the regulator for elastin expression may play an important role in elastogenesis and SMC proliferation during the development of atherosclerosis.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_10001_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110003641443","subitem_relation_type_select":"NAID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:10.1248/jhs.47.525","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本薬学会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11316464","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13449702","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wachi, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"130","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050318614","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"50318614","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50318614"}]},{"creatorNames":[{"creatorName":"Sugitani, Hideki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"693","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tajima, Shingo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"694","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seyama, Yoshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"595","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000090061283","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"90061283","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90061283"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-01"}],"displaytype":"detail","filename":"JHealthSci_47-6_p525.pdf","filesize":[{"value":"272.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JHealthSci_47-6_p525.pdf ","url":"https://stella.repo.nii.ac.jp/record/445/files/JHealthSci_47-6_p525.pdf"},"version_id":"1ed57300-6a6f-4f49-a0f9-ce9a04e007e3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"elastin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"lysyl oxidase","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelin-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"smooth muscle cell","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelin A receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Endothelin-1 Down-Regulates Expression of Tropoelastin and Lysyl Oxidase mRNA in Cultured Chick Aortic Smooth Muscle Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Endothelin-1 Down-Regulates Expression of Tropoelastin and Lysyl Oxidase mRNA in Cultured Chick Aortic Smooth Muscle Cells","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["126"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-01"},"publish_date":"2016-02-01","publish_status":"0","recid":"445","relation_version_is_last":true,"title":["Endothelin-1 Down-Regulates Expression of Tropoelastin and Lysyl Oxidase mRNA in Cultured Chick Aortic Smooth Muscle Cells"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-19T09:21:22.151705+00:00"}