{"created":"2023-06-19T09:07:03.098311+00:00","id":444,"links":{},"metadata":{"_buckets":{"deposit":"32bbee4c-b278-4498-92f2-6ff7327ab6d4"},"_deposit":{"created_by":15,"id":"444","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"444"},"status":"published"},"_oai":{"id":"oai:stella.repo.nii.ac.jp:00000444","sets":[]},"author_link":["692","116","690","33","470"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"204","bibliographicPageStart":"195","bibliographicVolumeNumber":"49","bibliographic_titles":[{"bibliographic_title":"Journal of health science"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The in vitro effects of various chemicals, such as styrene dimers, styrene trimers, alkylphenols, phthalate esters, phytoestrogens, and organotin compounds, on the production of interferon-gamma (IFN-γ), a type 1 helper T-cells (Th 1) specific cytokine, and interleukin-4 (IL-4), a type 2 helper T-cells (Th2) specific cytokine, which are secreted from anti CD3-stimulated mouse spleen cells, were examined. These chemicals suspected of having an endocrine disrupter function and to which humans may become exposed via ingestlon through food, food containers, and food packaging. It was found the organotin compounds bis(tributyltin) oxide, tributyltin chloride, and dibutyltin dichloride at concentrations which did not elicit any cytotoxicity inhibited secretion of the Th1 and Th2 specific cytokines IFN-γand IL-4 at concentrations (0.01-0.03, 0.07-0.1, and 0.096-0.132μM for IC_<50>, respectively) that were much lower than those of the other chemicals. However, these butyltin compounds exhibited similar degrees of inhibitory effects on IFN-γand IL-4 secretion and did not selectively inhibit the secretion of one or the other cytokine. However, diphenyltin dichloride and phenyltin trichloride enhanced the secretion of IL-4 at the comparatively low concentrations of 0.3 μM and 1.0 μM, respectively, although these compounds significantly inhibited IFN-γsecretion at the same concentrations. In addition, 4-t-pentylphenol enhanced IL-4 secretion although it inhibited IFN-γsecretion at the comparatively high concentration of 30 μM. It was also found that some styrene trimers, phthalate esters and fiavonoids as well as the alkyl phenols octylphenois and nonylphenol among others, inhibited the secretion of both cytokines at comparatively high concentrations (< 30 μM).","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_10001_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110003609062","subitem_relation_type_select":"NAID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:10.1248/jhs.49.195","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本薬学会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11316464","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13449702","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yano, Kazuma","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"692","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ohno, Shuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"470","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000020233223","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"20233223","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20233223"}]},{"creatorNames":[{"creatorName":"Nakajima, Yonako","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"690","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toyoshima, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"116","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000040092283","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000040092283"},{"nameIdentifier":"1000040092283","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"40092283","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40092283"}]},{"creatorNames":[{"creatorName":"Nakajin, Shizuo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"33","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000090101576","nameIdentifierScheme":"CiNii ID","nameIdentifierURI":"http://ci.nii.ac.jp/nrid/1000090101576"},{"nameIdentifier":"1000090101576","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"90101576","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90101576"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-01"}],"displaytype":"detail","filename":"JHealthSci_47-6_p525.pdf","filesize":[{"value":"272.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JHealthSci_47-6_p525.pdf ","url":"https://stella.repo.nii.ac.jp/record/444/files/JHealthSci_47-6_p525.pdf"},"version_id":"39f686b1-6577-411c-8171-68f79109dd92"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"spleen cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"type 1 helper T-cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"type 2 helper T-cells","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cytokines","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endocrine disrupters","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effects of Various Chemicals Including Endocrine Discuptors and Analogs on the Secretion of Th1 and Th2 Cytokines from Anti CD3-Stimulated Mouse Spleen Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effects of Various Chemicals Including Endocrine Discuptors and Analogs on the Secretion of Th1 and Th2 Cytokines from Anti CD3-Stimulated Mouse Spleen Cells","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["126"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-02-01"},"publish_date":"2016-02-01","publish_status":"0","recid":"444","relation_version_is_last":true,"title":["Effects of Various Chemicals Including Endocrine Discuptors and Analogs on the Secretion of Th1 and Th2 Cytokines from Anti CD3-Stimulated Mouse Spleen Cells"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-19T09:21:24.083972+00:00"}