{"created":"2023-06-19T09:07:02.690350+00:00","id":438,"links":{},"metadata":{"_buckets":{"deposit":"998ad1d8-b107-4bbb-b136-02e81de2af2d"},"_deposit":{"created_by":15,"id":"438","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"438"},"status":"published"},"_oai":{"id":"oai:stella.repo.nii.ac.jp:00000438","sets":[]},"author_link":["679","595","680","466","678","681","130"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"472","bibliographicPageStart":"468","bibliographicVolumeNumber":"55","bibliographic_titles":[{"bibliographic_title":"Journal of Health Science"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Transforming growth factor-β (TGF-β) is a potent growth factor that contributes to wound healing. TGF-β is usually secreted in a latent form complexed with its propeptide, latency-associated peptide (LAP), and LAP covalently binds to a molecule of latent TGF-β binding protein (LTBP). Fibrillin-1 sequesters TGF-β within connective tissue microfibrils through interaction with LTBP-1. However, it is not clear whether TGF-β bound to LTBP-1 is available during wound healing. Therefore, we further characterized LTBP-1, the extracellular regulator of TGF-β in wound healing. LTBP-1 fragments were released from skin by plasmin treatment. The LTBP-1 fragment that is similar to plasmin treatment was also detected in a wound surface. The enzymatic activity of plasmin was also detected in wound surfaces. Immunoblotting analyses showed that the LTBP-1 fragment was preferentially detected in a wound surface with proliferating granulation tissues. These results suggest that proteolytic release of LTBP-1 from a wound surface is physiological and important in regulating wound healing.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"The Pharmaceutical Society of Japan"}]},"item_10001_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"130000127925","subitem_relation_type_select":"NAID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1248/jhs.55.468","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"The Pharmaceutical Society of Japan"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11316464","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1344-9702","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mizuno, Koji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"466","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wachi, Hiroshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"130","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000050318614","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"50318614","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=50318614"}]},{"creatorNames":[{"creatorName":"Isogai, Zenzo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"678","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoneda, Masahiko","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"679","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fujii, Satoshi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"680","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Watanabe, Ken","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"681","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seyama, Yoshiyuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"595","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000090061283","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"90061283","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90061283"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-01-29"}],"displaytype":"detail","filename":"JHealthSci_55-3_p468.pdf","filesize":[{"value":"997.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"JHealthSci_55-3_p468.pdf ","url":"https://stella.repo.nii.ac.jp/record/438/files/JHealthSci_55-3_p468.pdf"},"version_id":"b41dd422-7bed-4635-ad4c-446eaa0c872b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"wound healing","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"latent transforming growth factor-β binding protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"plasmin","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Proteolytic Release of Latent Transforming Growth Factor-.BETA. (TGF-.BETA.) Binding Protein-1 (LTBP-1) Fragment in Wound Healing","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Proteolytic Release of Latent Transforming Growth Factor-.BETA. (TGF-.BETA.) Binding Protein-1 (LTBP-1) Fragment in Wound Healing","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["126"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-01-29"},"publish_date":"2016-01-29","publish_status":"0","recid":"438","relation_version_is_last":true,"title":["Proteolytic Release of Latent Transforming Growth Factor-.BETA. (TGF-.BETA.) Binding Protein-1 (LTBP-1) Fragment in Wound Healing"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-19T09:21:36.377704+00:00"}