{"created":"2023-06-19T09:07:01.073195+00:00","id":411,"links":{},"metadata":{"_buckets":{"deposit":"133d4d1e-089f-4431-986e-b9f8723e6f47"},"_deposit":{"created_by":15,"id":"411","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"411"},"status":"published"},"_oai":{"id":"oai:stella.repo.nii.ac.jp:00000411","sets":[]},"author_link":["143","514"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-07-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"1021","bibliographicPageStart":"1013","bibliographicVolumeNumber":"128","bibliographic_titles":[{"bibliographic_title":"藥學雜誌"},{"bibliographic_title":"Journal of the Pharmaceutical Society of Japan","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Macro- and microvascular disease states currently represent the principal causes of morbidity and mortality in patients with type I or type II diabetes mellitus. Abnormal vasomotor responses and impaired endothelium-dependent vasodilation have been demonstrated in various beds in different animal models of diabetes and in humans with type I or type II diabetes. The principal mediators of diabetes-associated vascular dysfunction are increases in glucose, oxidized low-density lipoprotein, endothelin-1, angiotensin II, insulin, or growth factors. An accumulating body of evidence indicates that abnormal production of oxidative stress may be one of several factors contributing to vascular dysfunction in diabetes. It is possible that in diabetic states, hyperinsulinemia initiates oxidant stress, leading to vascular dysfunction at a later stage. We and others have demonstrated that in models of hyperinsulinemia and hyperglycemia, ・NO production and/or ・NO responsiveness are impaired in aortic strips. Several recent studies have shown that the formation of nitrotyrosine and/or peroxynitrite impairs vascular ・NO responsiveness and ・NO production. Our findings suggest that the coexistence of a high insulin level and an established diabetic state may lead to the excessive generation of peroxynitrite, and that this may in turn trigger an impairment of endothelium-dependent relaxation via a decrease in sarcoendo plasmic reticulum Ca^<2+> ATPase function. This review summarizes the results of our recent studies on the involvement of insulin and oxidative stress in the blood vessels of diabetic animals.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_10001_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"110006792631","subitem_relation_type_select":"NAID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1248/yakushi.128.1013","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本薬学会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00284903","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"00316903","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小林, 恒雄"},{"creatorName":"コバヤシ, ツネオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"143","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000090339523","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"90339523","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90339523"}]},{"creatorNames":[{"creatorName":"Kobayashi, Tsuneo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"514","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000090339523","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"90339523","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90339523"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-01-29"}],"displaytype":"detail","filename":"YakuShi_128-7_p1013.pdf","filesize":[{"value":"974.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"YakuShi_128-7_p1013.pdf ","url":"https://stella.repo.nii.ac.jp/record/411/files/YakuShi_128-7_p1013.pdf"},"version_id":"36d77237-9570-4d97-8c0d-68e49909c0e7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"diabetes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"oxidative stress","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"insulin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"contraction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelium-dependent relaxation","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"糖尿病性血管合併症におけるインスリンと酸化ストレスについて","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"糖尿病性血管合併症におけるインスリンと酸化ストレスについて"},{"subitem_title":"Possible Involvement of Insulin and Oxidative Stress in Vascular Dysfunction of Diabetic Mellitus","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["125"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-01-29"},"publish_date":"2016-01-29","publish_status":"0","recid":"411","relation_version_is_last":true,"title":["糖尿病性血管合併症におけるインスリンと酸化ストレスについて"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-19T09:22:23.417268+00:00"}