{"created":"2023-06-19T09:07:00.672340+00:00","id":405,"links":{},"metadata":{"_buckets":{"deposit":"d1581223-b8f3-4a94-a2d0-8d2d5ee9a251"},"_deposit":{"created_by":15,"id":"405","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"405"},"status":"published"},"_oai":{"id":"oai:stella.repo.nii.ac.jp:00000405","sets":[]},"author_link":["146","512"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"784","bibliographicPageStart":"777","bibliographicVolumeNumber":"130","bibliographic_titles":[{"bibliographic_title":"YAKUGAKU ZASSHI"},{"bibliographic_title":"YAKUGAKU ZASSHI","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"  Vascular tone is tightly regulated by endothelium-derived factors. These include relaxing factors (EDRFs) such as nitric oxide (NO), hyperpolarizing factors (EDHFs), and contracting factors (EDCFs). Although EDHF is a prominent vasodilator, particularly in smaller arteries, little attention has been paid to the potential role of EDHF responses in diabetes. EDHF signaling may involve various factors, including several diffusible factors and non-diffusible factors (e.g., gap junctions). It has been demonstrated that the alterations in EDHF relaxation seen in mesenteric arteries from diabetic rats may be attributable to an increase in phosphodiesterase 3 (PDE3) activity, leading to a reduction in the action of adenosine 3',5'-cyclic monophosphate (cAMP), and consequently the activity of protein kinase A (PKA) is decreased in such arteries. Moreover, it has been suggested that the imbalance between EDRFs and EDCFs is present in mesenteric arteries from type 2 diabetic rats and the EDHF relaxation can be partly reversed by suppression of EDCF signaling. Indeed, chronic treatment with metformin, eicosapentaenoic acid, or thromboxane synthase inhibitor can reduce EDCF signaling and normalize EDHF signaling in mesenteric arteries from type 2 diabetic rats. Although the improvement or restoration of EDHF responses has not been the direct subject of any pharmaceutical effort, increasing cAMP/PKA signaling (e.g., by inhibiting PDE3 activity) or reducing EDCFs signaling has potential as an interesting therapeutic target in diabetic vasculopathy.","subitem_description_type":"Abstract"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_10001_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"130000259469","subitem_relation_type_select":"NAID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1248/yakushi.130.777","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本薬学会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00284903","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0031-6903","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"松本, 貴之"},{"creatorName":"マツモト, タカユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"146","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000030366835","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"30366835","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30366835"}]},{"creatorNames":[{"creatorName":"Matsumoto, Takayuki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"512","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000030366835","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"30366835","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30366835"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-01-29"}],"displaytype":"detail","filename":"YakuShi_130-6_p777.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"YakuShi_130-6_p777.pdf ","url":"https://stella.repo.nii.ac.jp/record/405/files/YakuShi_130-6_p777.pdf"},"version_id":"06d65881-d3e4-441b-8073-5be1be674167"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"endothelium-derived hyperpolarizing factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelial dysfunction","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"diabetes","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"adenosine 3',5'-cyclic monophosphate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"endothelium-derived contracting factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"prostanoids","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"糖尿病性血管合併症における内皮由来過分極因子の重要性と治療戦略へのアプローチ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"糖尿病性血管合併症における内皮由来過分極因子の重要性と治療戦略へのアプローチ"},{"subitem_title":"A Therapeutic Target for Endothelium-derived Hyperpolarizing Factor Signaling in Diabetic Vascular Complication","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["125"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-01-29"},"publish_date":"2016-01-29","publish_status":"0","recid":"405","relation_version_is_last":true,"title":["糖尿病性血管合併症における内皮由来過分極因子の重要性と治療戦略へのアプローチ"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-19T09:22:35.120199+00:00"}