{"created":"2023-06-19T09:07:00.238909+00:00","id":398,"links":{},"metadata":{"_buckets":{"deposit":"07cad5f7-c54d-4a86-a74b-cdd8fba00eb1"},"_deposit":{"created_by":15,"id":"398","owners":[15],"pid":{"revision_id":0,"type":"depid","value":"398"},"status":"published"},"_oai":{"id":"oai:stella.repo.nii.ac.jp:00000398","sets":[]},"author_link":["396","395"],"item_10001_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"961","bibliographicPageStart":"955","bibliographicVolumeNumber":"133","bibliographic_titles":[{"bibliographic_title":"YAKUGAKU ZASSHI"},{"bibliographic_title":"YAKUGAKU ZASSHI","bibliographic_titleLang":"en"}]}]},"item_10001_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10001_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"  Aquaporins (AQPs) are membrane channels that transport water within the human body and are therefore important for the regulation of water homeostasis. However, little is known regarding the details of the physiological role of AQP3, which is predominantly expressed in the colon. Thus, we investigated the role of AQP3 in the colon using laxative agents (magnesium sulfate and bisacodyl). The results suggest that the laxative effect produced by magnesium sulfate, which is classified as an osmotic laxative, is not simply a result of the changes in osmotic pressure but is also associated with the increased expression of AQP3 in the mucosal epithelial cells of the colon. In addition, magnesium sulfate increased colonic AQP3 expression through adenylate cyclase activation, which is caused by an increase in the intracellular Mg2+ concentration. This effect may trigger CREB phosphorylation through PKA activation and promote AQP3 gene transcription. Meanwhile, bisacodyl, which is classified as a stimulant laxative, decreases the expression level of AQP3 in the mucosal epithelial cells of the colon, resulting in the inhibition of water transfer from the intestinal tract to the vascular side of the epithelium, eventually leading to the development of diarrhea. It was also observed that the direct activation of colon macrophages by bisacodyl increases the secretion of PGE2, which acts as a paracrine factor and decreases AQP3 expression in colon mucosal epithelial cells. Future studies of the enteric AQP3 expression level and water transport may aid in the development of new laxative and antidiarrheal agents that target AQP3.","subitem_description_type":"Abstract"}]},"item_10001_description_6":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":" ","subitem_description_type":"Other"}]},"item_10001_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会"}]},"item_10001_relation_12":{"attribute_name":"論文ID（NAID）","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"130003361988","subitem_relation_type_select":"NAID"}}]},"item_10001_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"info:doi/10.1248/yakushi.13-00173","subitem_relation_type_select":"DOI"}}]},"item_10001_rights_15":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"日本薬学会"}]},"item_10001_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00284903","subitem_source_identifier_type":"NCID"}]},"item_10001_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0031-6903","subitem_source_identifier_type":"ISSN"}]},"item_10001_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"五十嵐, 信智"},{"creatorName":"イカラシ, ノブトモ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"395","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000040409363","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"40409363","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40409363"}]},{"creatorNames":[{"creatorName":"Ikarashi, Nobutomo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"396","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"1000040409363","nameIdentifierScheme":"NRID","nameIdentifierURI":" "},{"nameIdentifier":"40409363","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=40409363"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-01-28"}],"displaytype":"detail","filename":"YakuShi_133-9_p955.pdf","filesize":[{"value":"666.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"YakuShi_133-9_p955.pdf ","url":"https://stella.repo.nii.ac.jp/record/398/files/YakuShi_133-9_p955.pdf"},"version_id":"f70e580f-4c77-49fa-8502-9fb162c22424"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"aquaporin-3","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"colon","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"magnesium sulfate","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"bisacodyl","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"prostaglandin E2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"diarrhea","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"大腸におけるアクアポリン3の機能解析とその発現制御機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"大腸におけるアクアポリン3の機能解析とその発現制御機構の解明"},{"subitem_title":"The Elucidation of the Function and the Expression Control Mechanism of Aquaporin-3 in the Colon","subitem_title_language":"en"}]},"item_type_id":"10001","owner":"15","path":["125"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-01-28"},"publish_date":"2016-01-28","publish_status":"0","recid":"398","relation_version_is_last":true,"title":["大腸におけるアクアポリン3の機能解析とその発現制御機構の解明"],"weko_creator_id":"15","weko_shared_id":-1},"updated":"2023-06-19T09:22:48.547127+00:00"}