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Involvement of the Arachidonic Acid Cascade in the Hypersusceptibility to Pentylenetetrazole-Induced Seizure during Diazepam Withdrawal
https://stella.repo.nii.ac.jp/records/588
https://stella.repo.nii.ac.jp/records/58866d3b15d-002d-4c8b-921e-9f831b61e9fa
名前 / ファイル | ライセンス | アクション |
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BiolPharmBull_35‐12_p2243.pdf (422.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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公開日 | 2016-02-08 | |||||||
タイトル | ||||||||
言語 | en | |||||||
タイトル | Involvement of the Arachidonic Acid Cascade in the Hypersusceptibility to Pentylenetetrazole-Induced Seizure during Diazepam Withdrawal | |||||||
言語 | ||||||||
言語 | eng | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | diazepam withdrawal | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | arachidonic acid | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | glutamatergic pathway | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | quinacrine | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | nordihydroguaiaretic acid | |||||||
キーワード | ||||||||
言語 | en | |||||||
主題Scheme | Other | |||||||
主題 | diclofenac | |||||||
資源タイプ | ||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
資源タイプ | journal article | |||||||
著者 |
Mori, Tomohisa
× Mori, Tomohisa× Shimizu, Norifumi× Shibasaki, Masahiro
WEKO
422
× Suzuki, Tsutomu |
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抄録 | ||||||||
内容記述タイプ | Abstract | |||||||
内容記述 | The present study was designed to clarify whether the arachidonic acid cascade contributes to the decreased threshold for pentylenetetrazole-induced seizure under benzodiazepine withdrawal in mice. The seizure threshold for pentylenetetrazole was significantly decreased by the discontinuation of chronic treatment with diazepam. The decrease in the seizure threshold for pentylenetetrazole during diazepam withdrawal was significantly suppressed by intracerebroventricular (i.c.v.) pretreatment with the phospholipase A2 inhibitor quinacrine (30, 100 nmol) and the lipoxygenase inhibitor nordihydroguaiaretic acid (10, 30 nmol). In contrast, the decreased seizure threshold in the diazepam-withdrawal group was intensified by pretreatment with the cyclooxygenase inhibitor diclofenac (56 nmol). These compounds did not alter the threshold for seizure in a control group. These findings suggest that enhancement of the arachidonic acid cascade may contribute to the hypersusceptibility to pentylenetetrazole-induced seizure during diazepam withdrawal. | |||||||
書誌情報 |
Biological and Pharmaceutical Bulletin 巻 35, 号 12, p. 2243-2246, 発行日 2012 |
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出版者 | ||||||||
出版者 | 日本薬学会 | |||||||
ISSN | ||||||||
収録物識別子タイプ | ISSN | |||||||
収録物識別子 | 0918-6158 | |||||||
書誌レコードID | ||||||||
収録物識別子タイプ | NCID | |||||||
収録物識別子 | AA10885497 | |||||||
論文ID(NAID) | ||||||||
関連タイプ | isIdenticalTo | |||||||
識別子タイプ | NAID | |||||||
関連識別子 | 130002480507 | |||||||
DOI | ||||||||
関連タイプ | isIdenticalTo | |||||||
識別子タイプ | DOI | |||||||
関連識別子 | info:10.1248/bpb.b12-00542 | |||||||
権利 | ||||||||
権利情報 | 日本薬学会 | |||||||
フォーマット | ||||||||
内容記述タイプ | Other | |||||||
内容記述 | application/pdf | |||||||
著者版フラグ | ||||||||
出版タイプ | VoR | |||||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |