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Bootstrap Resampling Technique to Evaluate the Reliability of the Optimal Liposome Formulation: Skin Permeability and Stability Response Variables
https://stella.repo.nii.ac.jp/records/578
https://stella.repo.nii.ac.jp/records/578d5ec8757-4f63-45a2-a18f-292051de18e6
名前 / ファイル | ライセンス | アクション |
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BiolPharmBull_37‐9_p1543.pdf (8.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2016-02-08 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Bootstrap Resampling Technique to Evaluate the Reliability of the Optimal Liposome Formulation: Skin Permeability and Stability Response Variables | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | bootstrap | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | response surface | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | simultaneous optimal solution | |||||
キーワード | ||||||
言語 | en | |||||
主題Scheme | Other | |||||
主題 | transdermal drug delivery | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Duangjit, Sureewan
× Duangjit, Sureewan× Opanasopit, Praneet× Rojanarata, Theerasak× Takayama, Jun× Takayama, Kozo× Ngawhirunpat, Tanasait |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A nonlinear response surface method incorporating multivariate spline interpolation (RSM-S) is a useful technique for the optimization of pharmaceutical formulations, although the direct reliability of the optimal formulation must be evaluated. In this study, we demonstrated the feasibility of using the bootstrap (BS) resampling technique to evaluate the direct reliability of the optimal liposome formulation predicted by RSM-S. The formulation characteristics (Xn), including vesicle size (X1), size distribution (X2), zeta potential (X3), elasticity (X4), drug content (X5), entrapment efficiency (X6), release rate (X7), and the penetration enhancer (PE) factors as formulation factors (Zn), with the type of PE (Z1) and content of PE (Z2) were used as causal factors of the response surface analysis. The intended responses were high skin permeability (flux, Y1) and high stability formulation (drug remaining, Y2). Based on the dataset obtained, the simultaneous optimal solutions were estimated using RSM-S. Leave-one-out-cross-validation showed satisfying reliability of the optimal solution. Concurrently, similar BS optimal solutions were estimated from the BS dataset that was generated from the original dataset through BS resampling at frequencies of 250, 500, 750, and 1000. The analysis and simulation indicated that X4, X5, and Z2 were the prime factors affecting Y1 and Y2. These findings suggest that this approach could also be useful for evaluating the reliability of an optimal liposome formulation predicted by RSM-S and would be beneficial for the pharmaceutical development of liposomes for transdermal drug delivery. | |||||
書誌情報 |
Biological and Pharmaceutical Bulletin 巻 37, 号 9, p. 1543-1549, 発行日 2014 |
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出版者 | ||||||
出版者 | 日本薬学会 | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0918-6158 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10885497 | |||||
論文ID(NAID) | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | NAID | |||||
関連識別子 | 130004057439 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | info:10.1248/bpb.b14-00361 | |||||
権利 | ||||||
権利情報 | 日本薬学会 | |||||
フォーマット | ||||||
内容記述タイプ | Other | |||||
内容記述 | application/pdf | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 |