WEKO3
アイテム
Latent Structure Analysis of the Process Variables and Pharmaceutical Responses of an Orally Disintegrating Tablet
https://stella.repo.nii.ac.jp/records/463
https://stella.repo.nii.ac.jp/records/463bf112c8b-520d-4362-b66a-e936686859a7
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
ChemPharmBull_60‐11_p1419.pdf (2.1 MB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2016-02-03 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Latent Structure Analysis of the Process Variables and Pharmaceutical Responses of an Orally Disintegrating Tablet | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | multivariate analysis | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | orally disintegrating tablet | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | response surface method | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | optimization | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | process variable | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | Bayesian network | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 著者 |
Hayashi, Yoshihiro
× Hayashi, Yoshihiro
× Oshima, Etsuko
× Maeda, Jin
× Onuki, Yoshinori
× Obata, Yasuko
× Takayama, Kozo
|
|||||||||||||||||
| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | A multivariate statistical technique was applied to the design of an orally disintegrating tablet and to clarify the causal correlation among variables of the manufacturing process and pharmaceutical responses. Orally disintegrating tablets (ODTs) composed mainly of mannitol were prepared via the wet-granulation method using crystal transition from the δ to the β form of mannitol. Process parameters (water amounts (X1), kneading time (X2), compression force (X3), and amounts of magnesium stearate (X4)) were optimized using a nonlinear response surface method (RSM) incorporating a thin plate spline interpolation (RSM-S). The results of a verification study revealed that the experimental responses, such as tensile strength and disintegration time, coincided well with the predictions. A latent structure analysis of the pharmaceutical formulations of the tablet performed using a Bayesian network led to the clear visualization of a causal connection among variables of the manufacturing process and tablet characteristics. The quantity of β-mannitol in the granules (Qβ) was affected by X2 and influenced all granule properties. The specific surface area of the granules was affected by X1 and Qβ and had an effect on all tablet characteristics. Moreover, the causal relationships among the variables were clarified by inferring conditional probability distributions. These techniques provide a better understanding of the complicated latent structure among variables of the manufacturing process and tablet characteristics. | |||||||||||||||||
| 書誌情報 |
Chemical and Pharmaceutical Bulletin 巻 60, 号 11, p. 1419-1425, 発行日 2012 |
|||||||||||||||||
| 出版者 | ||||||||||||||||||
| 出版者 | 日本薬学会 | |||||||||||||||||
| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 0009-2363 | |||||||||||||||||
| 書誌レコードID | ||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA00602100 | |||||||||||||||||
| 論文ID（NAID） | ||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||
| 識別子タイプ | NAID | |||||||||||||||||
| 関連識別子 | 130001852385 | |||||||||||||||||
| DOI | ||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | info:10.1248/cpb.c12-00522 | |||||||||||||||||
| 権利 | ||||||||||||||||||
| 権利情報 | 日本薬学会 | |||||||||||||||||
| フォーマット | ||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | application/pdf | |||||||||||||||||
| 著者版フラグ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
