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Involvement of Reactive Oxygen Species in Abnormal Tropoelastin Deposition Induced by UVA-Photosensitizers
https://stella.repo.nii.ac.jp/records/437
https://stella.repo.nii.ac.jp/records/437d80f6c96-0251-4016-b3bf-b13459041531
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
JHealthSci_55-6_p946.pdf (336.8 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||
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| 公開日 | 2016-01-29 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | Involvement of Reactive Oxygen Species in Abnormal Tropoelastin Deposition Induced by UVA-Photosensitizers | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | photoaged | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | reactive oxygen species | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | skin fibroblast cells | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | tropoelastin | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 言語 | en | |||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||
| 主題 | ultraviolet A-irradiation | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||
| 著者 |
Onoue, Satoshi
× Onoue, Satoshi
× Nonaka, Risa
× Sato, Fumiaki
× Koide, Chiharu
× Hayashi, Akinobu
× Wachi, Hiroshi
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| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | Chronically, sun-exposed human skin is characterized by dermal connective tissue damage with the accumulation of abnormal elastic fibers. However, little is known about the relationship between accumulation of abnormal elastic fibers and photodamaged skin. In the present study, we investigated the involvement of reactive oxygen species (ROS) in photoaged skin including abnormal accumulation of tropoelastin (TE) induced by ultraviolet A (UVA)-irradiation using an in vitro model of elastic fiber formation. Our data showed that the morphological appearances of TE deposition was observed following the addition of recombinant TE immediately after treatment with UVA-irradiation by immunofluorescence staining and semi-quantitative assay. Our data also revealed that treatment with hypoxanthine-xanthine oxidase, which generates superoxide radicals, stimulated TE deposition. Furthermore, we confirmed that abnormal TE deposition induced by UVA-irradiation was inhibited by treatment with Cu/Zn superoxide dismutase, a superoxide radical scavenger. Therefore, the data obtained suggest that superoxide radical is a candidate for inducing morphological changes and increasing TE deposition induced by UVA-irradiation in human skin fibroblast cells. The present study would be helpful for developing a prophylactic agent for photoaged skin. | |||||||||||||||||
| 書誌情報 |
Journal of Health Science 巻 55, 号 6, p. 946-951, 発行日 2009 |
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| 出版者 | ||||||||||||||||||
| 出版者 | The Pharmaceutical Society of Japan | |||||||||||||||||
| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 1344-9702 | |||||||||||||||||
| 書誌レコードID | ||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||
| 収録物識別子 | AA11316464 | |||||||||||||||||
| 論文ID（NAID） | ||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||
| 識別子タイプ | NAID | |||||||||||||||||
| 関連識別子 | 130000127991 | |||||||||||||||||
| DOI | ||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||
| 関連識別子 | info:doi/10.1248/jhs.55.946 | |||||||||||||||||
| 権利 | ||||||||||||||||||
| 権利情報 | The Pharmaceutical Society of Japan | |||||||||||||||||
| フォーマット | ||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | application/pdf | |||||||||||||||||
| 著者版フラグ | ||||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||
