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Differential Effects of Two Types of Obesity on Ketone Body Utilization in Skeletal Muscle
https://stella.repo.nii.ac.jp/records/435
https://stella.repo.nii.ac.jp/records/43567f3975e-d39b-4fa0-ad41-1607ec7651be
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
JHealthSci_57-1_p93.pdf (344.3 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2016-01-29 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Differential Effects of Two Types of Obesity on Ketone Body Utilization in Skeletal Muscle | |||||||||||||||
| 言語 | en | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | acetoacetyl-CoA synthetase | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | obesity | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | leptin | |||||||||||||||
| キーワード | ||||||||||||||||
| 言語 | en | |||||||||||||||
| 主題Scheme | Other | |||||||||||||||
| 主題 | ketone body utilization | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 著者 |
Narishima, Ryota
× Narishima, Ryota
× Yamasaki, Masahiro
× Yoshida, Saki
× Hasegawa, Shinya
× Fukui, Tetsuya
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| 抄録 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | Previously, we showed that obesity affects the gene expression of acetoacetyl-CoA synthetase (AACS), the enzyme responsible for the utilization of ketone bodies for lipid synthesis, in adipocytes. Therefore, we examined whether obesity also changes the AACS level in skeletal muscle. AACS mRNA expression was decreased in the skeletal muscle of leptin-deficiency-induced obese rats. In undifferentiated C2C12 myoblast cells, a high concentration of glucose induced the expression of AACS mRNA but decreased the AACS level in differentiated C2C12 cells. Moreover, leptin directly increased the AACS mRNA level in C2C12 myocytes. The expression level of succinyl-CoA: 3-oxoacid CoA-transferase (SCOT), another enzyme that induces ketone body consumption, was not changed in C2C12 cells. Our results suggest that AACS gene expression is differently affected by leptin and glucose during muscle differentiation and leptin plays a regulatory role not only in lipid consumption but also in ketone body utilization via AACS in skeletal muscle. | |||||||||||||||
| 書誌情報 |
Journal of Health Science 巻 57, 号 1, p. 93-98, 発行日 2011 |
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| 出版者 | ||||||||||||||||
| 出版者 | The Pharmaceutical Society of Japan | |||||||||||||||
| ISSN | ||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||
| 収録物識別子 | 1344-9702 | |||||||||||||||
| 書誌レコードID | ||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||
| 収録物識別子 | AA11316464 | |||||||||||||||
| 論文ID（NAID） | ||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||
| 識別子タイプ | NAID | |||||||||||||||
| 関連識別子 | 130000425129 | |||||||||||||||
| DOI | ||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||
| 関連識別子 | info:doi/10.1248/jhs.57.93 | |||||||||||||||
| 権利 | ||||||||||||||||
| 権利情報 | The Pharmaceutical Society of Japan | |||||||||||||||
| フォーマット | ||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||
| 内容記述 | application/pdf | |||||||||||||||
| 著者版フラグ | ||||||||||||||||
| 出版タイプ | VoR | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||
