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アイテム
Detailed Analysis of Clinical Test Data on Chemotherapy for Colorectal Cancer
https://stella.repo.nii.ac.jp/records/401
https://stella.repo.nii.ac.jp/records/401f74f1368-9cf8-45db-aa01-1c4da5e8041a
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
YakuShi_131-5_p765.pdf (802.9 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||||||||
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| 公開日 | 2016-01-29 | |||||||||||||||||||||
| タイトル | ||||||||||||||||||||||
| タイトル | Detailed Analysis of Clinical Test Data on Chemotherapy for Colorectal Cancer | |||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 言語 | ||||||||||||||||||||||
| 言語 | eng | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | spline interpolation | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | time series analysis | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | chemotherapy | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | bone-marrow suppression | |||||||||||||||||||||
| キーワード | ||||||||||||||||||||||
| 言語 | en | |||||||||||||||||||||
| 主題Scheme | Other | |||||||||||||||||||||
| 主題 | clinical test | |||||||||||||||||||||
| 資源タイプ | ||||||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||||||
| 資源タイプ | journal article | |||||||||||||||||||||
| 著者 |
Sotoishi, Noboru
× Sotoishi, Noboru
× Yoshimatsu, Kazuhiko
× Yokomizo, Hajime
× Katsube, Takao
× Nishimura, Junji
× Yakou, Shigeru
× Ogawa, Kenji
× Takayama, Kozo
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| 抄録 | ||||||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||||||
| 内容記述 | We reported previously that spline interpolation is effective as a pretreatment before analyzing clinical data by time series. However, further improvement is required to understand the detailed tendency of clinical data. In this study, the tendency of interpolated hematological data was investigated in the period between the most tolerated dose (MTD) and low-dose chemotherapy (LDC) for colorectal cancer. All patients were received both MTD and LDC. Hematological data, white blood cell count (WBC), red blood cell count (RBC) and mean corpuscular volume (MCV), were interpolated. The accuracy of interpolation was verified using leave-one-out cross-validation. The difference, Δi, was calculated from interpolated data and exhibited as a function of time. The predictions of RBC and MCV were accurate with high correlation coefficients, although the interpolation of WBC data was inaccurate. A marked difference was observed in the trend of Δi between LDC and MTD periods. SD-RBC showed significant differences between LDC and MTD periods. The SD-MCV average in the LDC period was larger than in the MTD period. SD-MCV showed no significant difference. An attractor plot of Δi in RBC clarified the tendency of the interpolated RBC data. There is a possibility that Δi of RBC and/or SD-RBC may contribute to monitoring adverse reactions and decision of medication. Moreover, it is also useful to check on attractor plot of Δi in RBC together with SD-RBC in order to find out untoward reactions and decision of medication. | |||||||||||||||||||||
| 書誌情報 |
YAKUGAKU ZASSHI en : YAKUGAKU ZASSHI 巻 131, 号 5, p. 765-773, 発行日 2011 |
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| 出版者 | ||||||||||||||||||||||
| 出版者 | 日本薬学会 | |||||||||||||||||||||
| ISSN | ||||||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||||||
| 収録物識別子 | 0031-6903 | |||||||||||||||||||||
| 書誌レコードID | ||||||||||||||||||||||
| 収録物識別子タイプ | NCID | |||||||||||||||||||||
| 収録物識別子 | AN00284903 | |||||||||||||||||||||
| 論文ID（NAID） | ||||||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||||||
| 識別子タイプ | NAID | |||||||||||||||||||||
| 関連識別子 | 130000678859 | |||||||||||||||||||||
| DOI | ||||||||||||||||||||||
| 関連タイプ | isIdenticalTo | |||||||||||||||||||||
| 識別子タイプ | DOI | |||||||||||||||||||||
| 関連識別子 | info:doi/10.1248/yakushi.131.765 | |||||||||||||||||||||
| 権利 | ||||||||||||||||||||||
| 権利情報 | 日本薬学会 | |||||||||||||||||||||
| フォーマット | ||||||||||||||||||||||
| 内容記述タイプ | Other | |||||||||||||||||||||
| 内容記述 | application/pdf | |||||||||||||||||||||
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| 出版タイプ | VoR | |||||||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||||||||||||
