| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2016-01-28 |
| タイトル |
|
|
タイトル |
直接的レニン阻害剤ラジレス®錠の物理薬剤学的特性に対する温度と湿度の影響 |
| タイトル |
|
|
タイトル |
Influence of Temperature and Humidity on Physico-pharmaceutical Characteristics of Rasilez® Tablets |
|
言語 |
en |
| 言語 |
|
|
言語 |
jpn |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
Rasilez® tablet |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
moisture absorption |
| キーワード |
|
|
言語 |
en |
|
主題Scheme |
Other |
|
主題 |
physico-pharmaceutical characteristic |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
中村, 有貴
中島, 孝則
岩田, 政則
林, 祥弘
高山, 幸三
齋藤, 博
佐古, 兼一
松田, 佳和
木村, 正幸
Nakamura, Yuki
Nakajima, Takanori
Iwata, Masanori
Hayashi, Yoshihiro
Takayama, Kozo
Saito, Hiroshi
Sako, Kenichi
Matsuda, Yoshikazu
Kimura, Masayuki
|
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Rasilez® tablets (RTs) contain the active ingredient aliskiren, which is a direct renin inhibitor of the renin-angiotensin system and used for the treatment of hypertension. We examined the influence of temperature and humidity on the physico-pharmaceutical characteristics (mass, volume, hardness, elution) of RTs. The RTs were preserved under conditions in which the temperature and humidity were altered using the second-order spherical composite experimental design for multi-objective problems. The characteristics of RTs were influenced more by the humidity than temperature, and differed markedly with over 55% relative humidity (RH). The mass and volume were increased with increasing humidity, and the tablets swelled. The hardness after vacuum-drying of the tablets, which preserved moisture conditions, was increased. Semitransparent particles were observed in the cross-section of the drying tablets in which aliskiren crystal forms were changed to amorphous forms. The mean dissolution time (MDT) of tablets was reduced with increasing humidity. The critical relative humidity (CRH) of the tablets was 36.1%RH at 30°C. These results suggest that RTs, on moisture absorption, showed changes in not their appearance and hardness, but also in crystal forms and the elution characteristics of aliskiren. |
| 内容記述 |
|
|
内容記述タイプ |
Other |
| 書誌情報 |
YAKUGAKU ZASSHI
en : YAKUGAKU ZASSHI
巻 134,
号 4,
p. 555-561,
発行日 2014
|
| 出版者 |
|
|
出版者 |
日本薬学会 |
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
0031-6903 |
| 書誌レコードID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AN00284903 |
| 論文ID（NAID） |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
NAID |
|
|
関連識別子 |
130003391189 |
| DOI |
|
|
関連タイプ |
isIdenticalTo |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
info:doi/10.1248/yakushi.13-00245 |
| 権利 |
|
|
権利情報 |
日本薬学会 |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
| 著者版フラグ |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
YakuShi_134-4_p555.pdf (790.2 kB)
